SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model

摘要

Background: c-Jun N-terminal kinase (JNK) relays extracellular stimuli through phosphorylation cascades that lead to various cell responses. In the present study, we aimed to investigate the effect of the JNK inhibitor SP600125 on the resolution of airway inflammation, and the underlying mechanism using a murine acute asthma model.