Comparative Study of Tumor Targeting and Biodistribution of pH (Low) Insertion Peptides (pHLIP(A (R)) Peptides) Conjugated with Different Fluorescent Dyes

摘要

Acidification of extracellular space promotes tumor development, progression, and invasiveness. pH (low) insertion peptides (pHLIP(A (R)) peptides) belong to the class of pH-sensitive membrane peptides, which target acidic tumors and deliver imaging and/or therapeutic agents to cancer cells within tumors.