In Vitro and In Vivo Characterization of Two C-11-Labeled PET Tracers for Vesicular Acetylcholine Transporter

摘要

The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. Herein, two potent and selective C-11-labeled VAChT inhibitors were evaluated in rodents and nonhuman primates for imaging VAChT in vivo.