Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3'-Deoxy-3'-[F-18]-fluorothymidine PET

Chan Pei-Chia; Wu Chun-Yi; Chou Lin-Shan; Ho Chung-Hsien; Chang Chi-Wei; Chiou Shih-Hwa; Lin Wuu-Jyh; Chen Fu-Du; Chang C. Allen; Hwang Jeng-Jong; Liu Ren-Shyan; Wang Hsin-Ell

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Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3'-Deoxy-3'-[F-18]-fluorothymidine PET

机译：使用3'-脱氧-3'-[F-18]-氟胸苷PET监测组蛋白脱乙酰基酶抑制剂治疗后的肿瘤反应

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This study employed 3'-deoxy-3'-[F-18]-fluorothymidine ([F-18]FLT) microPET scanning to assess the treatment response of histone deacetylase inhibitors (HDACi), e.g., N1-hydroxy-N8-phenyloctanediamide (SAHA) and its iodinated derivative ISAHA, in a hepatoma mouse model.

机译：这项研究采用3'-脱氧-3'-[F-18]-氟胸苷（[F-18] FLT）microPET扫描来评估组蛋白脱乙酰基酶抑制剂（HDACi）的治疗反应，例如N1-羟基-N8-苯基辛二酰胺（SAHA）及其碘化衍生物ISAHA，用于肝癌小鼠模型。

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《Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging》 |2015年第3期|共9页
作者
Chan Pei-Chia; Wu Chun-Yi; Chou Lin-Shan; Ho Chung-Hsien; Chang Chi-Wei; Chiou Shih-Hwa; Lin Wuu-Jyh; Chen Fu-Du; Chang C. Allen; Hwang Jeng-Jong; Liu Ren-Shyan; Wang Hsin-Ell;
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正文语种 eng
中图分类诊断学;
关键词
F-18FLT; HDACi; Treatment response; MicroPET; Hepatocellular carcinoma;

机译：[F-18] FLT;HDACi;治疗反应;MicroPET;肝细胞癌;

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1. Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3'-Deoxy-3'-[F-18]-fluorothymidine PET [J] . Chan Pei-Chia, Wu Chun-Yi, Chou Lin-Shan, Molecular imaging and biology: MIB : the official publication of the Academy of Molecular Imaging . 2015,第3期

机译：使用3'-脱氧-3'-[F-18]-氟胸苷PET监测组蛋白脱乙酰基酶抑制剂治疗后的肿瘤反应
2. Use of 3'-deoxy-3'-(18F)fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors. [J] . Yang YJ, Ryu JS, Kim SY, European Journal of Nuclear Medicine and Molecular Imaging . 2006,第4期

机译：使用3'-脱氧-3'-（18F）氟胸苷PET监测鼠SCCVII肿瘤对放射治疗的早期反应。
3. Monitoring early response to taxane therapy in advanced breast cancer with circulating tumor cells and [ 18F] 3?-deoxy-3?- fluorothymidine PET: A pilot study [J] . ContractorK., AboagyeE.O., JacobJ., Biomarkers in medicine . 2012,第2期

机译：用循环肿瘤细胞和[18F]3α-脱氧-3β-氟胸苷PET监测晚期乳腺癌紫杉烷疗法的早期反应：一项先导研究
4. The Tricyclic Antidepressant Amitriptyline Inhibits D-Cyclin Transactivation and Induces Myeloma Cell Apoptosis by Inhibiting Histone Deacetylases: In Vitro and In Silico Evidence [C] . Xinliang Mao, Depei Wu, Suzanne Trudel, International conference of molecular simulations and applied informatics technologies . 2012

机译：三环抗抑郁药阿米替林通过抑制组蛋白脱乙酰基酶抑制D-cyclin反式激活并诱导骨髓瘤细胞凋亡：体外和计算机证据。
5. Upregulation of Somatostatin Receptor 2 in Neuroendocrine Tumors Using Histone Deacetylase Inhibitors [D] . Guenter, Rachael. 2021

机译：用组蛋白脱乙酰酶抑制剂对神经内分泌肿瘤进行生长抑素受体2的上调
6. Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors [O] . Mario Federico, Luigi Bagella 2011

机译：组蛋白脱乙酰基酶抑制剂治疗血液系统恶性肿瘤和实体瘤
7. Low-dose histone deacetylase inhibitor treatment leads to tumor growth arrest and multi-lineage differentiation of malignant rhabdoid tumors [O] . Muscat, Andrea, Popovski, Dean, Jayasekara, W. Samantha N., 2016

机译：低剂量组蛋白脱乙酰基酶抑制剂治疗可导致肿瘤生长停滞和恶性横纹肌瘤的多系分化
8. Modulation of Breast Tumor Cell Response to Retinoids by Histone Deacetylase Inhibitors [R] . Sacchi, N. 2003

机译：组蛋白去乙酰化酶抑制剂调节乳腺肿瘤细胞对类视黄醇的反应

Monitoring Tumor Response After Histone Deacetylase Inhibitor Treatment Using 3'-Deoxy-3'-[F-18]-fluorothymidine PET

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