Engineering Biology: Model Conceptualisation and Realisation

摘要

A model of the lysis-lysogeny decision cycle of the Phage-lambda virus has been re-implemented using standard engineering tools. The model is based on previous systems biology-based work and is constructed using the biological knowledge of the protein signalling networks within the virus. It explores how the emergent effects from the protein interactions produce the observed lysis-lysogeny behaviour. The software tools used (LabVIEW~(TM) and MATLAB~(TM)) were chosen as they do not require specialised biochemical knowledge and have a wide industrial user base. This modelling is done as part of Project Fallot at Loughborough University, which is producing multiscale models of congenital heart disease. Part of this research requires a model of Delta-Notch protein signalling. Comment is made on the applications of the implemented modelling technique for modelling of Delta Notch protein signalling in cells.