EFFECTS OF CO-ADMINISTRATION OF CALCIUM AND SPICES MIXTURE ON RENAL FUNCTION PARAMETERS OF LEAD EXPOSED RATS

摘要

This work evaluated the effect of co-administration of calcium and spices mixture (SM) on renalfunction parameters of lead exposed rats. Twenty five (25) male Albino rats weighing 100-123.3 gwere used for the study. The animals were grouped into five (5) groups (I-V) of five rats per group.Group I received feed and water and served as the negative control. Group II received only leadchloride (25 mg/Kg body weight) and served as the positive control. Group III was co-administered750 mg/Kg weight of calcium carbonate and 25 mg/Kg body weight of lead chloride. Group IV wasco-administered 300 mg/Kg body weight of extract of spice mixture (SM) and 25mg/Kg body weightof lead chloride while group V was co-administered 300 mg/kg body weight of extract of spicesmixture, 25 mg/Kg body weight of lead chloride and 750 mg/Kg body weight of calcium carbonate.All treatment was orally administered. The treatment lasted for 42 days after which blood sampleswere collected for the determination of renal function parameters and serum electrolytes usingstandard techniques and methods. The result showed significantly (p0.05) higher plasma uric acid,creatinine, and urea in lead exposed rats in comparison to the non-exposed group. These biochemicalalterations were however almost restored to the levels found in the non-exposed animals followingadministration of either calcium or spices mixture alone or when both were co-administered. Coadministration of SM plus calcium, or administration of calcium alone or SM alone may haveameliorative effect on lead-induced kidney dysfunction in rats.