Formulation direct compression tablet of probiotic as vehicle for oral delivery

摘要

© 2017 by Kermanshah University of Medical Sciences.There has been an explosion of probiotic health-based products. Many reports indicated that there is poor survival of probiotic bacteria in these products. For oral delivery of probiotic, providing living cells with a physical barrier against adverse environmental conditions is considerable interest. The main goal of the study was to develop tablets made out of functional polymers in order to protect probiotic bacteria from gastric acidity, thus providing an easily manufacturing scale-up dosage form to deliver probiotics to the human intestinal. Tablets were produced by direct compression using Microcrystalline Cellulose (Avicel®) as main exipient. To optimize the formulation, using survival rate after both compressing and exposed pH: 2 acid medium were evaluated. Storage stability of lactobacilluse acidophiluse tablets was also performed by evaluation of viable cells throughout 3 months at 4 °C. The highest viability was found in formulation 7 and 8 with 90.37 and 90.27 after compression pressure. Increasing amount of Avicel® in the tablet increase bacterial viability against pressure. 72.51 Survival was showed is related to formulation 3 after exposure acid. It can be concluded that The best protective qualities against artificial gastric juice were observed when tablets were prepared from compaction mixtures of lactic acid bacteria (LAB), sodium alginate, and Xanthan. A decrease of approximately one logarithmic cycle was observed after 3 month storage for formula 3 while untreated cell decrease 3.97 log. This preparation method and tablet formulation can be employed for intestinal delivery to ensure maximum viable cell release at intestine or colon and this product remains stable until the time of consumption.