The conflict between the locality of general relativity, reflected in its space-time description, and the non-locality of quantum mechanics, contained in its Hilbert space description, is discussed. Gauge covariant non-local observables that depend on gauge fields and gravity as well as the wave function are used in order to try to understand and minimize this conflict within the frame-work of these two theories. Applications are made to the Aharonov-Bohm effect and its generalizations to non Abelian gauge fields and gravity. [References: 13]
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