Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding

摘要

Pt((CN)-N-boolean AND)(phe) (1, (CN)-N-boolean AND = 2-(2'-thienyl)pyridirie, phe = phenylalanine) shows a high binding affinity (ca. 10(6) dm(3) mol(-1)) and selectivity towards human serum albumin (HSA) and such binding is accompanied by an enhancement of photoluminescence at 562 nm; both the protein binding affinity and cytotoxicities of Pt((CN)-N-boolean AND)(phe) (1), Pt((CN)-N-boolean AND)(trp) (2, trp = tryptophan) and Pt((CN)-N-boolean AND)(gly) (3, gly = glycine) are affected by the amino acid ligand with 1 having an IC50 of up to 1 mu M against a number of carcinoma cell lines.