Proteomics versus Transcriptomics for the Identification of Cancer Biomarkers: the Case of Brain-derived Metastatic Breast Cancer Cells

摘要

Transcriptomics and proteomics have become common approaches in the search to identify new cancer biomarkers. However, it is unclear how well cancer-associated changes in protein and mRNA expression match, as a study from the same set of cancer samples has not been reported. Here we have compared changes in the proteome versus transcriptome in the brain-derived metastatic breast cancer cell line, 231 -BR, as compared to the parental line, MDA-MB-231, which is also highly metastatic but with no organ selectivity.