[Role of tanycytes within the blood-hypothalamus interface].

摘要

Information exchanges between the brain and the periphery are key stages in the regulation of various physiological functions. The mediobasal hypothalamus, which ensures a large part of these functions, must be permanently informed about the physiological state of the body to guarantee the maintaining of homeostasis. For that purpose, it possesses a peculiar blood-brain interface due to the presence of specialized glial cells called tanycytes. This review describes the organization of the blood-hypothalamus interface and characterizes the peculiar place of tanycytes within it, as well as their striking capacity to remodel their own interface in order to ensure the regulation of various physiological functions.