PALLADIUM- AND NORBORNENE-CATALYZED SYNTHESIS OF HIGHLY FUNCTIONALIZED THIOPHENES: THE REMARKABLE EFFECT OF ELECTRON-POOR OLEFINS AS LIGAND

摘要

Highly functionalized heterocyclic compounds were synthesized by palladium and norbornene catalysis starting from ortho-substituted aryl iodides, aryl bromides and 3,4-ethylenedioxythiophene. The addition of methyl cinnamate to the reaction mixture was found to be crucial in order to obtain selectively the unsymmetrical product.