TRIPHOSGENE-MEDIATED CHLOROLACTAMIZATION AND AMINOLACTAMIZATION OF HOMOALLYLIC AMINES

摘要

Two types of aminocarbonylation reaction of homoallylic amines have been developed. The treatment of homoallylic amines with triphosgene in dichloromethane led to formation of the corresponding beta-chlorolactams via Prins-type cyclization of a carbamoyl chloride intermediate. For the reaction in acetonitrile, beta-aminolactams were obtained via sequential Prins-type cyclization and Ritter-type reactions.