SYNTHESIS OF LAMELLARINS VIA REGIOSELECTIVE ASSEMBLY OF 1,2-DIARYLATED 1BENZOPYRANO3,4-bPYRROL-4(3H)-ONE CORE

摘要

A modular synthesis of lamellarins has been developed. The key reactions in this synthesis are the assembly of 1,2-diarylated 1benzopyrano-3,4-bpyrrol-4(3H)-ones from a preexisting 1benzopyrano 3,4-bpyrrol4(3H)-one core and the appropriate arylboronic acids. The obtained 1,2-diarylated 1benzopyrano3,4-bpyrrol-4(3H)-ones could be easily converted into the corresponding lamellarin derivatives by intramolecular annulation between the pyrrole nitrogen and the C2 aromatic ring.