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17HSD 2 may be Higher in African-American Breast Cancer and is Associated with Estrogen Receptor-negative Tumors

机译:17HSD 2在非裔美国乳腺癌中可能更高,并且与雌激素受体阴性肿瘤相关

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Background: African-American women develop more aggressive breast cancers and at an earlier age compared with Caucasian women. Materials and Methods: We compared gene expression profiles of breast cancer cell lines that were developed from African-American and Caucasian patients to identify biological differences in breast cancers that develop in these groups Real-time PCR was used to evaluate mRNA expression in cell lines and in a series of breast cancer cases. Gene microarray signal intensities were also analyzed in the International Genomics Consortium Expression Project for Oncology (expO) dataset. Results: 17beta-Hydroxysteroid dehydrogenase type 2 (17HSD 2) gene and mRNA expression were significantly higher in the African-American cell lines (p<0.05). However, 17HSD 2 expression did not differ significantly between the two cohorts in either our clinical series or the expO dataset. 17HSD 2 expression was found to be predictive of younger age at diagnosis and estrogen receptor status. Conclusion: Overexpression of 17HSD 2 in African-American breast cancer may contribute to the increased proportion of estrogen receptor-negative breast cancers and worse clinical outcome among African-American patients.
机译:背景:与白人女性相比,非裔美国人女性罹患更具侵略性的乳腺癌,且年龄更早。材料和方法:我们比较了从非洲裔美国人和高加索人患者开发的乳腺癌细胞系的基因表达谱,以鉴定在这些组中发展的乳腺癌的生物学差异。实时PCR用于评估细胞株中mRNA的表达。在一系列乳腺癌病例中。基因微阵列信号强度也在国际肿瘤基因表达联合会表达计划(expO)数据集中进行了分析。结果:非裔美国人细胞系中的17beta-羟基类固醇脱氢酶2型(17HSD 2)基因和mRNA表达显着较高(p <0.05)。但是,在我们的临床系列或expO数据集中的两个队列之间,17HSD 2表达没有显着差异。发现17HSD 2表达可预测诊断时的年龄和雌激素受体状态。结论:17HSD 2在非裔美国乳腺癌中的过表达可能导致雌激素受体阴性乳腺癌的比例增加,并且在非裔美国人患者中临床预后较差。

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