STYLISSAMIDE I, A NEW CYCLIC HEPTAPEPTIDE FROM AN OKINAWAN MARINE SPONGE STYLISSA sp.

摘要

A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cydo-(L-Tyr(1)-L-Tyr(2)-L-Tyr(3)-L-Pro(1)-L-Pro(2)-L-Val-L-Pro(3)) by extensive spectral analyses and Marfey's method. Stylissamide I (1) showed antifungal activity against Aspergillus niger.