Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.

摘要

As an example of a multi-template approach, we focused on the 3,3-diphenylpentane (DPP) skeleton, which has been demonstrated to act as a steroid skeleton substitute. Various ligands for nuclear receptors (NRs), including vitamin D receptor (VDR), androgen receptor (AR) and farnesoid X receptor (FXR), and inhibitors of steroid metabolism-related enzymes, including 5alpha-reductase and HMG-CoA reductase (HMGR), have been efficiently created by introducing various substituents onto the DPP skeleton.