New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

摘要

The rescarch into selective ligands of misfolded protein plaques in Alzheimer's disease and in transmissible spongiform cncephalopathies ded to compound 3, based on the congo Red framework and bearing two trifluoromethoxy groups. Histochcmical expcrimcnts on human brain tissues showed miensc huorcscont staining of flbrillary doposits in both pathologics