New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma

Teuma Cecile; Perier-Muzet Marie; Pelletier Solenne; Nouvier Mathilde; Amini-Adl Mona; Dijoud Frederique; Duru Gerard; Thomas Luc; Fouque Denis; Laville Maurice; Dalle Stephane

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New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma

机译：B-RAF抑制剂vemurafenib对转移性黑色素瘤患者肾毒性的新见解

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Vemurafenib (VMF) is a B-RAF inhibitor used in the treatment of B-RAF-V600-mutant metastatic melanomas. Reports of acute kidney injury (AKI) in patients treated with VMF are scarce.

机译：Vemurafenib（VMF）是一种B-RAF抑制剂，用于治疗B-RAF-V600突变的转移性黑色素瘤。缺乏接受VMF治疗的患者的急性肾损伤（AKI）的报道。

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来源
《Cancer chemotherapy and pharmacology.》 |2016年第2期|共8页
作者
Teuma Cecile; Perier-Muzet Marie; Pelletier Solenne; Nouvier Mathilde; Amini-Adl Mona; Dijoud Frederique; Duru Gerard; Thomas Luc; Fouque Denis; Laville Maurice; Dalle Stephane;
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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Kidney failure; BRAF inhibitor; Vemurafenib; Metastatic melanoma;

机译：肾衰竭;BRAF抑制剂;维拉非尼;转移性黑色素瘤;

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专利

1. New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma [J] . Teuma Cecile, Perier-Muzet Marie, Pelletier Solenne, Cancer chemotherapy and pharmacology. . 2016,第2期

机译：B-RAF抑制剂vemurafenib对转移性黑色素瘤患者肾毒性的新见解
2. Dabrafenib and trametinib combination therapy safely performed in a patient with metastatic melanoma after severe liver toxicity due to vemurafenib [J] . Shimada Shuichi, Fukushima Satoshi, Niimori Daisuke, The Journal of dermatology . 2018,第6期

机译：Dabrafenib和Trametinib组合疗法在严重肝脏毒性由于Vemurafenib而患有转移性黑色素瘤的患者中进行
3. Cutaneous toxicities associated with vemurafenib therapy in 107 patients with BRAF V600E mutation-positive metastatic melanoma, including recognition and management of rare presentations [J] . Sinha R., Larkin J., Gore M., British Journal of Dermatology . 2015,第4期

机译：韦拉非尼疗法对107例BRAF V600E突变阳性转移性黑色素瘤患者的皮肤毒性，包括罕见病的识别和治疗
4. Prediction of Metastatic Events in Patients With Cutaneous Melanoma [C] . Christian Scheibboeck, Patrick Huber, Stefanie Weber, International Conference on eHealth, Telemedicine, and Social Medicine . 2013

机译：皮肤黑素瘤患者转移事件预测
5. Mouse oocyte maturation and embryo development after exposure to Vemurafenib (plx4032), an anti-melanoma B-RafV600E inhibitor. [D] . Liu, Bo. 2014

机译：暴露于抗黑素瘤B-RafV600E抑制剂Vemurafenib（plx4032）后，小鼠卵母细胞成熟和胚胎发育。
6. B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells [O] . Wynand P. Roos, Steve Quiros, Andrea Krumm, 2014

机译：B-Raf抑制剂vemurafenib与替莫唑胺和fotemustine联用对恶性黑色素瘤细胞的杀伤反应
7. B-Raf inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells [O] . Wynand P. Roos, Steve Quiros, Andrea Krumm, 2014

机译：B-RAF抑制剂vemurafenib与替莫唑胺和Fotemustine组合在恶性黑素瘤细胞的杀伤反应中

New insights into renal toxicity of the B-RAF inhibitor, vemurafenib, in patients with metastatic melanoma

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