Thin-layer chromatographic studies of some angiotensin converting enzyme inhibitors and their...

摘要

The aim of this paper is to examine the chromatographic behaviour of some angiotensin converting enzyme (ACE) inhibitors (lisinopril, fosinopril, zofenopril) under conditions of direct phase thin-layer chromatography (Kiselgel 60) and their inclusion complexes with β-cyclodextrin using reversed phase thin-layer chromatography (Kiselgel 60 F254 silaniziert). Binary systems angiotensin converting enzyme inhibitor-β-cyclodextrin were prepared using the kneading method, in 1:1 molar ratio. The thin-layer chromatography reveals that the inclusion complexes show lower hRf values compared to the two components of the inclusion complex, proving that there is an interaction between the active substances and β-cyclodextrin, due to the formation of the inclusion complexes.