Antimicrobial Resistance in Commensal Flora of Pig Farmers

摘要

We assessed the quantitative contribution of pig farm-ing to antimicrobial resistance in the commensal flora of pigfarmers by comparing 113 healthy pig farmers from themajor French porcine production areas to 113 nonfarmers,each matched for sex, age, and county of residence. Allreported that they had not taken antiimicrobial agents with-in the previous month. Throat, nasal, and fecal swabs werescreened for resistant microorganisms on agar containingselected antimicrobial agents. Nasopharyngeal carriage ofStaphylococcus aureus was significantly more frequent inpig farmers, as was macrolide resistance of S. aureus fromcarriers. Nongroupable streptococci from the throat weremore resistant to the penicillins in pig farmers. The intestin-al isolation of enterococci resistant to erythromycin or van-comycin was not significantly higher in pig farmers incontrast to that of enterobacteria resistant to nalidixic acid,chloramphenicol, tetracycline, and streptomycin. Preva-lence of resistance in predominant fecal enterobacteriawas also significantly higher in pig farmers for cotrimoxa-zole, tetracycline, streptomycin, and nalidixic acid. Wedetermined a significant association between pig farmingand isolation of resistant commensal bacteria