Mitogenic activity of whole cells and cell wall components of Lactobacillus acidophilus group lactic acid bacteria on murine spleen and Peyer's patch cells.

摘要

The mitogenic activities of the whole cells of the 40 strains of the L. acidophilus group and the cell wall components from selected strains were evaluated using murine spleen and Peyer's patch cells. The whole cells of many of the strains showed ahigh mitogenic response. The cell wall of L. gasseri LA158 was a B-Cell mitogen. Acidic polysaccharide (APS) and peptidoglycan (PG) isolated from the cell wall of LA158 showed strong mitogenic activity in both cells. No teichoic acids were found in the cell wall of this strain. Neutral polysaccharide and acidic polysaccharide (APS) consisted of D-glucose (glucan), and the latter contained 1.0% (w/w) phosphorus. The stimulation activity on lymphocytes shown by the whole cells of LA158 was thought to be induced by APS and PG.