A Simple and Convenient Method for the Synthesis of 1-Methyl-7-arylfuro3,2-gpteridine-2,4(1H,3H)-diones and Their Substituted Derivatives

摘要

A simple and effective method for the synthesis of unknown 1-methyl-7-arylfuro3,2-gpteridine-2,4(1H,3H)-diones by dehydration of the corresponding 1-methyl-6-phenacyl-pteridine-2,4,7(1H,3H,8H)-triones is reported in the article. It was shown that their alkylation by butyl chloroacetate in basic medium proceeded by the N-3-atom of the heterocycle. The structure and purity of the synthesized compounds were confirmed by IR, H-1, C-13 NMR spectroscopy, gas chromatography-mass spectrometry, mass spectrometry, as well as X-ray diffraction analysis. The proposed mechanism of the dehydration reaction was discussed.