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Implantable electrode array with platinum black coating for brain stimulation in fish

机译:具有铂黑涂层的可植入电极阵列,用于鱼的脑刺激

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摘要

Electrical stimulation of certain part of the neural tissue could evoke specific functional response. The interface plays an important role in stimulation process. Tungsten wire electrodes have long been used as an ideal interface for neural signal recording and stimulation. In this work, an electrode array with good electrochemical property and biocompatibility was successfully fabricated in a novel and convenient way. A PDMS electrode holder was made to fix the electrodes with certain distance. To achieve a better stimulation effect, a platinum black coating was electroplated, and the electrochemical properties of the electrode were tested. Tests results of the impedance and charge injection capacity showed great improvement in electrochemical property. To test the durability of the platinum black coating, the electrode was dealt with ultrasound vibration for 10 min and then re-tested for charge storage capacity lost. The array was then implanted into the midbrain of crucian carp by a surgical procedure. A stimulation pulse was applied in order to elicit a change in locomotion. By stimulating the midbrain part of the fish brain, both side turning movements were observed. Also, this work provides the fundamental experiment for the development of bio-robotic fish.
机译:对神经组织某些部分的电刺激可引起特定的功能反应。该界面在刺激过程中起重要作用。钨丝电极长期以来一直用作神经信号记录和刺激的理想接口。在这项工作中,以新颖和方便的方式成功地制造了具有良好的电化学性能和生物相容性的电极阵列。制作PDMS电极支架,以固定一定距离固定电极。为了获得更好的刺激效果,电镀了铂黑涂层,并测试了电极的电化学性能。阻抗和电荷注入容量的测试结果显示出电化学性能的极大改善。为了测试铂黑涂层的耐久性,将电极用超声波振动处理10分钟,然后重新测试失去的电荷存储能力。然后通过外科手术将该阵列植入into鱼的中脑。施加刺激脉冲以引起运动的改变。通过刺激鱼脑的中脑部分,观察到两侧转向运动。而且,这项工作为开发生物机器人鱼类提供了基础实验。

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