Synthesis of anionic peptide nucleic acid oligomers including gamma-carboxyethyl thymine monomers

摘要

Synthesis of a modified thymine monomer based on L-Glu, solid phase synthesis of anionic peptide nucleic acid (PNA) oligomers containing the modified monomer and optimization of the deblocking procedure and cleavage conditions of the PNA oligomers from resin are accomplished.