The next generation of positron emission tomography radiopharmaceuticals labeled with non-conventional radionuclides

摘要

The nuclear and chemical properties of 'non-traditional' positron emission tomography (PET) radionuclides, i.e. Sc-44, (61,64)cu, Ga-68, Y-86, Zr-89, as well as their production routes are discussed. The bio-conjugation of these radionuclides with various vectors for target delivery to tumor cells using bifunctional chelating agents is reviewed. The applications of various radiopharmaceuticals with 'non-traditional' PET radionuclides for molecular visualization of various tumors are summarized.