Reduction of infarction volume by bolus injection of pamiteplase, a modified tissue plasminogen activator with a longer half-life.

摘要

Using a rat model of thromboembolic stroke we evaluated whether or not fibrinolysis by bolus injection of pamiteplase, a modified tissue plasminogen activator (tPA) with a longer half-life, reduces infarction volume. Infarction volume was significantly reduced by the early administration of pamiteplase at 2 h after the onset of ischemia. Hemorrhagic infarction was observed only in 3 of 10 rats (30) treated at 6 h. Thus, bolus injection of pamiteplase can reduce infarction volume suppressing the incidence of hemorrhage.