Mannich Synthesis of Acetylenic Amino Alcohols in Aqueous Ionic Liquids

摘要

Terminal alkynols react with formaldehyde and secondary amines in aqueous ionic liquid [emim]HSO - 4 in the presence of Cu(OAc) to afford the corresponding 1-(a-hydroxyalkyl)- or 1-(b-hydroxyalkyl)-2- (aminomethyl)acetylenes in better yields in comparison with the reaction in conventional organic solvents. The catalytic system can be easily recovered and recycled.