Incidence of the L858R and G719S mutations of the epidermal growth factor receptor oncogene in an Ecuadorian population with lung cancer.

摘要

The World Health Organization indicates that lung cancer (LC) represents the main cause of death in many developed countries. In Ecuador, according to the National Cancer Registry, LC is the fourth cause of death among malignant tumors, followed by gastric, pancreatic, and breast cancer [1]. Moreover, three provinces present the highest percentages of the disease - Guayas (32.8%), Pi-chincha (20.7%), and Manabf (7.5%) [1]. It is estimated that this tendency will increase in the next years, and would place this disease as the principal cause of death by neoplasia. Therefore, it is important to perform the first mutation research in relation to the tyrosine kinase domain (TKD) of the EGFR gene in Ecuador.