Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

Tedeschi Philip M.; Kathari Yamini K.; Johnson-Farley Nadine; Bertino Joseph R.

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Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

机译：甲基硫代腺苷磷酸化酶（MTAP）缺陷的T细胞ALL异种移植物单独或联合使用对普雷曲酯和6-硫鸟嘌呤敏感

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摘要

To investigate the effectiveness of a combination of 6-thioguanine (6-TG) and pralatrexate (PDX) in methylthioadenosine phosphorylase (MTAP)-deficient T-cell acute lymphoblastic leukemia (T-cell ALL).

机译：要研究6-硫鸟嘌呤（6-TG）和普拉瑞克斯（PDX）联合治疗甲硫腺苷磷酸化酶（MTAP）缺陷的T细胞急性淋巴细胞白血病（T细胞ALL）的有效性。

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《Cancer chemotherapy and pharmacology.》 |2015年第6期|共6页
作者
Tedeschi Philip M.; Kathari Yamini K.; Johnson-Farley Nadine; Bertino Joseph R.;
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正文语种 eng
中图分类药理学;
关键词
T-cell acute lymphoblastic leukemia; Methylthioadenosine phosphorylase; 6-Thioguanine; Pralatrexate; Antifolate;

机译：T细胞急性淋巴细胞性白血病;甲硫腺苷磷酸化酶;6-硫鸟嘌呤;百拉美酯;抗叶酸;

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1. Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination [J] . Tedeschi Philip M., Kathari Yamini K., Johnson-Farley Nadine, Cancer chemotherapy and pharmacology. . 2015,第6期

机译：甲基硫代腺苷磷酸化酶（MTAP）缺陷的T细胞ALL异种移植物单独或联合使用对普雷曲酯和6-硫鸟嘌呤敏感
2. Independent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma [J] . Woollard Wesley J., Kalaivani Nithyha P., Jones Christine L., The Journal of investigative dermatology. . 2016,第6期

机译：在原发性皮肤T细胞淋巴瘤中甲基硫代腺苷磷酸化酶（MTAP）的独立损失。
3. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma. [J] . Kadariya Y, Yin B, Tang B Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009,第14期

机译：甲基硫代腺苷磷酸化酶（MTAP）的种系突变杂合的小鼠过早死于T细胞淋巴瘤。
4. Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination [O] . Philip M. Tedeschi, Yamini K. Kathari, Nadine Johnson-Farley, -1

机译：甲基硫代腺苷磷酸化酶（MTAP）缺陷的T细胞ALL异种移植物单独或联合使用对普拉雷特和6-硫鸟嘌呤敏感
5. Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination [O] . 2015

机译：甲基硫代腺苷磷酸化酶（MTAP）缺陷的T细胞ALL异种移植物单独或联合使用对普雷曲酯和6-硫鸟嘌呤敏感

Methylthioadenosine phosphorylase (MTAP)-deficient T-cell ALL xenografts are sensitive to pralatrexate and 6-thioguanine alone and in combination

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