Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

摘要

Five new acyclic amides, clausenalansamides C-G (1-5), clausenaline G (6) and (+/-)-5-(4-methylphenyl)-gamma-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1-5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 +/- 0.3 and 6.8 +/- 1.1 mu M, respectively.