Voltammetric determination of N-acetylcysteine using a carbon paste electrode modified with copper(II) hexacyanoferrate(III)

摘要

The preparation and electrochemical characterization of a carbon paste electrode modified with copper(II) hexacyanoferrate(III) (CuHCF) as well as its behavior as electrocatalyst toward the oxidation of N-acetylcysteine were investigated. The electrochemical behavior of the modified electrode and the electrooxidation of N-acetylcysteine were explored using sweep linear voltammetry. The best voltammetric response was observed for a paste composition of 20% (w/w) copper(II) hexacyanoferrate(III) complex, acetate buffer solution at pH of 6.0 as the electrolyte and scan rate of 10 mV s(-1). A linear voltammetric response for N-acetylcysteine was obtained in the concentration range from 1.2 x 10(-4) to 8.3 x 10(-4) mol L-1, with a detection limit of 6.3 x 10(-5) mol L-1. The proposed electrode is useful for the quality control and routine analysis of N-acetylcysteine in pharmaceutical formulations. (c) 2006 Elsevier B.V. All rights reserved.