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首页> 外文期刊>Metabolic brain disease >Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate.
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Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate.

机译:褪黑素可减少喹啉酸诱导的大鼠脑匀浆脂质过氧化反应。

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摘要

The protective effects of melatonin against the neurotoxin, quinolinic acid, were investigated in rat brain homogenate using the thiobarbituric acid assay. Quinolinic acid increased lipid peroxidation in a dose dependent manner. When homogenate was cotreated with melatonin there was a significant decrease in lipid peroxidation. The results of the present report show that melatonin may play a protective role in the brain against the neurohormone quinolinic acid, which has been identified as a causative agent in Huntington's Disease.
机译:使用硫代巴比妥酸试验,在大鼠脑匀浆中研究了褪黑素对神经毒素喹啉酸的保护作用。喹啉酸以剂量依赖性方式增加脂质过氧化作用。当匀浆与褪黑素共同处理时,脂质过氧化作用显着降低。本报告的结果表明,褪黑激素可能在脑中对神经激素喹啉酸起保护作用,后者已被确认为亨廷顿舞蹈病的病因。

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