Expression of PTEN and survivin in cervical cancer: promising biological markers for early diagnosis and prognostic evaluation

摘要

Uterine cervical cancer develops from precancerous lesions such as cervical intraepithelial neoplasia (CIN) and cervical glandular intraepithelial neoplasia (CGIN) to early invasive carcinoma to infiltrating carcinoma. The incidence and progression of cervical cancer involves the activation of multiple oncogenes and deactivation of inhibiting genes. The phosphatase and tensin (PTEN) homologue deleted on chromosome 10 was the first anti-oncogene discovered to exhibit double specific phosphatase activities; deactivation and mutation of this gene in tumours and cells has been reported to cause abnormal expression of corresponding proteins.1 Survivin, encoded by a recently discovered oncogene, inhibits cell apoptosis, promotes cell proliferation, and participates in angiopoiesis, an important molecular event during tumourigenesis.In this study, PTEN and survivin expression in cervix tissues is detected in order to explore the underlying mechanism of PTEN and survivin in cervical cancer progression. Furthermore, it investigates a new method for early diagnosis and prognosis of cervical cancer and explores potential gene therapy biological targets for cervical cancer.