Cytokine gene polymorphisms of TNFalpha, IL-6, IL-10, TGFbeta and IFNgamma in the Saudi population

摘要

Cytokines are signalling molecules that play important roles in regulating the immune and inflammatory responses. They are key components in the pathogenesis of many diseases, including cancer, metabolic disorders, autoimmune diseases and inflammatory conditions." Differences in cytokine gene polymorphisms are associated with disease predisposition,4 such as that for systemic lupus erythematosus (SLE),5 inflammatory bowel disease,6-7 rheumatoid arthritis,8 juvenile arthritis,9 type I diabetes,1011 and in patients presenting with sepsis.12 Although most studies are limited by their study design and sample size, it is noteworthy that such associations have been observed.