Opposite associations between alanine aminotransferase and gamma-glutamyl transferase levels and all-cause mortality in type 2 diabetes: Analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

摘要

Aims. Reported associations between liver enzymes and mortality may not hold true in type 2 diabetes, owing to a high prevalence of non-alcoholic fatty liver disease, which has been linked to cardiovascular disease and mortality in its own right. Our study aimed to determine whether alanine aminotransferase (ALT) or-gamma-glutamyl transferase (GGT) levels predict mortality in type 2 diabetes, and to examine possible mechanisms.