A definitive guide to the blood-brain barrier

摘要

The mechanisms thai maintain a "privileged" environment within the brain have been the subject of intense scrutiny for decades (1-4). While numerous authoritative reviews and primary research articles (6,001 listed in a search limiting ihe topic only to APS-sponsored publications) have appeared over the years, a recent entry into the literature stands out for its comprehensive nature and its focus on both the physiology and patho-physiology of the barrier (5). This highly readable and well-illustrated document details the mechanisms that establish the barrier, consequences of barrier dysfunction, and strategies for bypassing the barrier for therapeutic purposes.