PHYTOCHEMICAL AND BIOLOGICAL STUDY OF VANGUERIA EDULIS CULTIVATED IN EGYPT

摘要

Fractionation and purification of the alcoholic extract of the leaves and stem bark of Vangueria edulis cultivated in Egypt afforded thirteen compounds identified as: beta-sitosterol acetate (1), stigmasterol (2), palmitic acid (3), scopoletin (4), p-coumaric acid (5), protocatechuic acid (6), esculetin (7), ethyl 1-O-glucosyl-4-O-(E) caffeoyl quinate (8), kaempferol 3-O-rhamnoside, 7-O-rutinoside (9), fi-sitosterol (10), ceryl alcohol (11), vanillic acid (12) and fi-sitosterol-3-O-fi-D-glucopyranoside (13). Identification of these compounds has been established by physical, chemical and spectral data as well as comparison with authentic samples. Compounds 8 and 9 are firstly reported from a natural source while the rest of the compounds have been isolated for the first time from the genus Vangueria. The LD_(50), antibacterial, antifungal, anti-inflammatory, antipyretic and the effect on CNS were studied.