Rabbit model in the pre-clinical studies of a new generation of coronary stents

摘要

Coronary artery occlusion is a very important problem in human medicine. In 2010 in Poland, only approx. 188,006 coronary angiographies were performed, 105,728 of which ended in a Percutaneous Coronary Intervention (PCI) (23). In order to prevent heart infarcts and to maintain the patency of the coronary artery in a critical stenosis, a stent is inserted (implanted), which represents a kind of scaffolding (made of metal) that supports the wall of the vessel.Stent implantation is a procedure which belongs to the PCI group and is nowadays the most often perfor-med procedure in human interventional cardiology, constituting 90% of all PCI procedures (23.29). Before their introduction in routine therapies, permanent implants, such as stents, are subject to clinical evaluation, and earlier, to pre-clinical evaluation in animals.