Influence of meloxicam on cellular and humoral defense mechanisms.

摘要

The aim of this study was to determine the influence of meloxicam, a non-steroidal antiinflammatory drug, on the nonspecific cellular and humoral defence mechanisms in cows. A total of 10 heifers were divided into 2 groups (experimental and control) and examined. Meloxicam was given once only to the experimental group during the course of the study. The levels of lysozyme activity and total protein as well as ceruloplasmin, gamma-globulin and metabolic activity (RBA), macrophage activity (PKA) and proliferative response of lymphocytes were measured in the blood. The results indicated the immunosuppressive effect of meloxicam on the nonspecific cellular and humoral responses which, in practice, could appear as an increased sensitivity to infection, a decrease in post-vaccination immunity as well as the occurrence of various asymptomatic infections..