CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients A prospective, randomized study

摘要

Background: The aims of this study were to compare the efficacy and safety of the addition of adefovir dipivoxil (ADV) (started at different time points) to pegylated interferon alpha-2a (PEG-INF-alpha 2a) and PEG-INF-alpha 2a monotherapy. This prospective, randomized study sought to evaluate the safety and efficacy of the combination of PEG-INF-alpha 2a and ADV at different time points. 120 patients were randomized into groups that received PEG-INF-alpha 2a as monotherapy (group A) or in combination with ADV started at week 0 (group B), 12 (group C), or 24 (group D). All patients were followed for 48 weeks. Efficacy and safety analyses were performed.