We aim to investigate whether the phenomenon of sudden drop in blood pressure (BP) within the first 2 hours is associated with vessel recanalization.We retrospectively examined clinical and imaging data from a consecutive series of patients with stroke with large vessel occlusion treated with intravenous thrombolysis (IVT). BP was monitored every 15 minutes during the first 2 hours, then every 30 minutes for 6 hours, and then every hour for 16 hours.We observed the phenomenon of sudden drop in systolic BP (20mm Hg) in 82 (50.9%) patients in the first 2 hours and vessel recanalization in 87 (54.0%) patients 24 hours after treatment. This phenomenon was independently associated with recanalization (odds ratio 2.100; 95% confidence interval: 1.085-4.062; P=0.028) after adjusting for the history of atrial fibrillation, coronary heart disease, and hypertension.The phenomenon of sudden drop in systolic BP with 20mm Hg or greater between 2 continuous measurements within the first 2 hours is associated with recanalization after IVT in patients with large vessel occlusion, especially for middle cerebral artery occlusion.
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机译：我们的目的是调查在最初2小时内血压突然下降（BP）的现象是否与血管再通有关。我们回顾性研究了连续系列静脉溶栓治疗的大血管阻塞性卒中患者的临床和影像学数据（IVT）。在头2小时内每15分钟监测一次BP，然后每30分钟监测6小时，然后每小时监测16小时。我们观察到82例（50.9％）患者的收缩压（20mm Hg）突然下降。在治疗后24小时内对87名（54.0％）患者进行了前2小时的血管再通。在调整了心房纤颤，冠心病和高血压病史后，该现象与再通无关（赔率2.100; 95％置信区间：1.085-4.062; P = 0.028）。在大血管闭塞的患者中，尤其是对于大脑中动脉闭塞的患者，在前2小时内连续2次连续测量之间20mm Hg或更高，与IVT后的再通有关。
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