Ultra-short acting neuromuscular blocking agents; di- and tri-substituted benzyl bisquaternary ammonium derivatives of bis(tropan-3< alpha >-ol)-diesters

摘要

Based on previous experiences with bisquaternary ammonium derivatives of bistropine esters of dicarboxylic acids we designed, synthesized and pharmacologically evaluated seventy dicarboxylic acid esters of tropine (tropan-3< alpha >-ol) bearing substituted N-benzyl quaternizing groups. Many of the quaternary derivatives of these bistropine diesters showed high neuromuscular blocking potency, very short onset and ultrashort or short duration of action in experimental animals.