METAL CHELATES AS ORAL POTENTIAL INSULIN ADJUVANTS: STUDIES ON SOME OXOVANADIUM(IV) CHELATES INVOLVING BIOMIMETIC 07V0-DONOR SUGARS

摘要

The ability of sugars to sequester metals is of current interest in the possible development of metal chelates for clinical use and as models for biologically important compounds1. These studies could be advanced by the development of methods by which metals can be readily attached to sugars.The design of vanadium compounds with an optimal impact and a minimized toxicity has been a task of several research groups2. For any complex considered for therapeutic use it is important to consider the intrinsic toxicity of the ligand, especially if the treatment is predicted for a long period. In this context sugars or amino sugars may be interesting ligands as normally they are non-toxic compounds. Introducing an anchoring group into a sugar molecule, which as a primary coordinating site may promote the deprotonation/coordination of the alcoholic hydroxyl groups, the complex-forming ability may be enhanced several orders of magnitude.