Variation in bioactive content in Andrographis paniculata Nees at different growth stages

摘要

An investigation was carried out to study the effect of plant age on different morphological characters and the corresponding changes in the bioactive compound (andrographolide) in the three accessions of Andrographis paniculata. The results have shown significant differences and changes in the andrographolide content and yield at various growth stages of the plant. The three accessions with no morphological differences were characterized using RAPD and ISSR profiles and the variation in andrographolide content was estimated by HPLC. A plant age of 80-105 DAT (days after transplantation) may be recommended for harvesting to get a good andrographolide yield though the highest herbage yield may be obtained at 120 DAT. [Medicinal Plants 2014; 6(1) : 53-61]