Clinicopathological and prognostic significance of cancer stem cell markers CD44 and CD133 in patients with gastric cancer A comprehensive meta-analysis with 4729 patients involved

摘要

Background: In recent years, CD44 and CD133 have been identified as 2 common used cancer stem cell (CSC) markers in gastric cancer. However, the clinicopathological and prognostic value of these markers in gastric cancer remains controversial; moreover, there is lack of comparison of these 2 markers' roles in clinical applications. A systematic review and meta-analysis was conducted to elucidate these markers' clinicopathological features and association with prognosis in patients with gastric cancer.