Synthesis and preliminary antibacterial evaluation of hydroxamic acid and N-formyi hydroxylamine derivatives bearing oxazole ring

摘要

Three hydroxamic acids and seven N-formyl hydroxylamine derivatives containing oxazole ring have, been designed and synthesized. The structures of target compounds were characterized on the basis of spectral (FT-IR, ~1H NMR, and HRMS) analysis. All the final synthesized compounds were evaluated in vitro against Staphylococcus aureus, Streptococcus pneumonia, Esche-richia coli, and Pseudomonas aeruginosa. Among them, 10a exhibited good activity against E. coli compared with the reference agent ciprofloxacin hydrochloride.