Synthesis and antitumor activity of (4-hydroxyphenyl) [5-substitutedalkyl/aryl)-2-thioxo-l,3,4-thiadiazol-3-yl]methanone and [(3,4-disubstituted)-l,3-thiazol-2ylidene]-4-hydroxybenzohydrazide

摘要

To examine new drug leads with potential anticancer activity, some (4-hydroxyphenyl)[5-substituted alkyl/aryl)-2-thioxo-l,3,4-thiadiazol-3-yl]methanone (4.a— 4.c) and [-(3,4-disubstituted)-l,3-thiazol-2ylidene)]-4-hy-droxybenzohydrazide (6.a-6.d) were synthesized using appropriate synthetic route. The newly prepared compounds 4.a-4.c and 6.a-6.d demonstrated inhibitory effects on the growth of a wide range of cancer cell lines especially on leukemia (HL-60), non-small lung cancer (HOP-92), renal cancer (ACHN) at the range of GI_(50) -4.23 to -7.23.