Interaction Between Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Angiotensin-Converting Enzyme Inhibition on Survival in Hemodialyzed Patients

摘要

The association between ACE (angiotensin-converting enzyme) gene insertion/deletion (I/D) polymorphism and mortality has been inconsistently observed in earlier studies in patients on maintenance hemodialysis. We hypothesized that the effect of ACE gene I/D polymorphism on mortality may be influenced by concurrent ACE inhibitor therapy in this population.