Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors

Ye Xiangyun; Sun Yinjia; Xu Yunhua; Chen Zhiwei; Lu Shun

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Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors

机译：肺癌相关的肿瘤丙酮酸激酶M2（PKM2）抑制剂的体内联合体外研究。

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Background: The tumor pyruvate kinase M2 (PKM2) is involved in the glycolytic pathway of lung cancer and targeting this kinase has been observed to radiosensitize non-small cell lung cancer (NSCLC).

机译：背景：丙酮酸肿瘤激酶M2（PKM2）参与肺癌的糖酵解途径，并且已观察到以该激酶为靶标对非小细胞肺癌（NSCLC）放射致敏。

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《Medicinal chemistry》 |2016年第7期|共8页
作者
Ye Xiangyun; Sun Yinjia; Xu Yunhua; Chen Zhiwei; Lu Shun;
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正文语种 eng
中图分类医用化学;
关键词
Tumor pyruvate kinase M2; kinase inhibitor; virtual screening; lung cancer;

机译：肿瘤丙酮酸激酶M2;激酶抑制剂;病毒筛查;肺癌;

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1. Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors [J] . Ye Xiangyun, Sun Yinjia, Xu Yunhua, Medicinal chemistry . 2016,第7期

机译：肺癌相关的肿瘤丙酮酸激酶M2（PKM2）抑制剂的体内联合体外研究。
2. Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro [J] . Yuan Sujuan, Qiao Tiankui, Zhuang Xibing, Yonsei Medical Journal . 2016,第6期

机译：用shRNA敲除丙酮酸激酶（PKM2）的M2亚型可增强多西他赛对人NSCLC细胞株的体外作用
3. Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [ 18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression [J] . Chirag B. Patel, Corinne Beinat, Yuanyang Xie, Neoplasia: an international journal for oncology research . 2021,第1期

机译：肿瘤处理田间（TTFIELDS）含有胶质母细胞瘤中的异常糖酵解，如[ 18-sup> f] dasa-23，丙酮酸激酶m2（pkm2）表达的非侵入性探针所评估
4. Association between tumor heterogeneity and progression-free survival in non-small cell lung cancer patients with EGFR mutations undergoing tyrosine kinase inhibitors therapy [C] . Jiangdian Song, Di Dong, Yanqi Huang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2016

机译：接受酪氨酸激酶抑制剂治疗的EGFR突变非小细胞肺癌患者肿瘤异质性与无进展生存的关系
5. The M2 splice isoform of pyruvate kinase is a phosphotyrosine binding protein critical for tumor cell metabolism and proliferation. [D] . Christofk, Heather Renee. 2007

机译：丙酮酸激酶的M2剪接同工型是对肿瘤细胞代谢和增殖至关重要的磷酸酪氨酸结合蛋白。
6. Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell Lines In Vitro [O] . Sujuan Yuan, Tiankui Qiao, Xibing Zhuang, 2016

机译：用shRNA敲除丙酮酸激酶（PKM2）的M2亚型可增强多西他赛对人NSCLC细胞株的体外作用
7. Knockdown of the M2 Isoform of Pyruvate Kinase (PKM2) with shRNA Enhances the Effect of Docetaxel in Human NSCLC Cell LinesIn Vitro [O] . Sujuan Yuan, Tiankui Qiao, Xibing Zhuang, 2016

机译：丙酮酸激酶（PKM2）的M2同种型与shRNA的敲低增强了多西紫杉醇在人NSCLC细胞系中的作用

Integrated In Silico-In Vitro Discovery of Lung Cancer-related Tumor Pyruvate Kinase M2 (PKM2) Inhibitors

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